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5′-Methylthioadenosine
$50 – $150
Products Details
Product Description
– 5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5′-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5′-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].
Web ID
– HY-16938
Storage Temperature
– -20°C (Powder, protect from light)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C11H15N5O3S
References
– [1]Yaofeng Li, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.|[2]Tang Y, et al. 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.|[3]Li Y, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.|[4]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.
CAS Number
– 2457-80-9
Molecular Weight
– 297.33
Compound Purity
– 99.67
SMILES
– NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSC)O3
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease
Solubility
– DMF : 2.5 mg/mL (ultrasonic)|DMSO : 50 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic)
Target
– Apoptosis;Endogenous Metabolite;Parasite
Isoform
– Human Endogenous Metabolite;Microbial Metabolite
Pathway
– Anti-infection;Apoptosis;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
