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Product Description
– 5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1].
Web ID
– HY-108453
Shipping
– Room temperature
Molecular Formula
– C37H39IO9
References
– [1]Seabrook GR, et, al. Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther. 2002 Dec;303(3):1052-60. |[2]Shimizu I, et, al. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro. J Pharmacol Exp Ther. 2005 Sep;314(3):1378-85.
CAS Number
– 535974-91-5
Molecular Weight
– 754.60
SMILES
– O=C(OCC(C[C@]12O)=C[C@]3([H])[C@@]4([C@]2([H])C=C(C)C1=O)[C@H](C)C[C@@]5(C(C)=C)[C@]3([H])O[C@](O4)(CC6=CC=CC=C6)O5)CC7=CC(OC)=C(O)C(I)=C7
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– TRP Channel
Isoform
– TRPV
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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