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5-Azacytidine
Price range: 53 CAD through 162 CAD
Products Details
Product Description
– 5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autophagy and has antitumor activity.
Web ID
– T1339
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C8H12N4O5
Citations
– 1. Wang W, Ren S, Lu Y, et al. Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production. The EMBO Journal. 2021 Jun 1;40(11):e106771. doi: 10.15252/embj.2020106771. Epub 2021 Apr 28.
2. Łagosz-Ćwik K, Melnykova M, Nieboga E, et al.Mapping of DNA methylationsensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis.Frontiers in Immunology.2023, 14.
3. Small S H, Perez R E, Beauchamp E M, et al.Targeting SLFN11-Regulated Pathways Restores Chemotherapy Sensitivity in AML.Blood Neoplasia.2024: 100037.
References
– Gailhouste L, et al. Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells. Cell Death Dis. 2018 May 1;9(5):468.
CAS Number
– 320-67-2
Molecular Weight
– C8H12N4O5
Compound Purity
– 0.9962
SMILES
– O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)N=C2
Target
– Others
Pathway
– DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Autophagy|||Microbiology/Virology
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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