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4′-Demethylepipodophyllotoxin
$60 – $78
Products Details
Product Description
– 4′-Demethylepipodophyllotoxin (4′-DMEP) is an intermediate compound that inhibits microtubule assembly.
Web ID
– HY-17435
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H20O8
References
– [1]Tang YJ, Zhao W, Li HM. Novel tandem biotransformation process for the biosynthesis of a novel compound, 4-(2,3,5,6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin. Appl Environ Microbiol. 2011 May;77(9):3023-34.|[2]Dhawan D, Balasubramanian S, Amonkar AJ, Chemopreventive effect of 4′-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis. Carcinogenesis. 1999 Jun;20(6):997-1003.|[3]Xiang Zhou, et al. The discovery of natural 4′-demethylepipodophyllotoxin from renewable Dysosma versipellis species as a novel bacterial cell division inhibitor for controlling intractable diseases in rice. Industrial Crops and Products. Volume 174, 15 December 2021, 114182
CAS Number
– 6559-91-7
Molecular Weight
– 400.38
Compound Purity
– 99.75
SMILES
– O=C1OC[C@]2([H])[C@H](O)C3=C(C=C4OCOC4=C3)[C@@H](C5=CC(OC)=C(O)C(OC)=C5)[C@]21[H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
