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4μ8C
Price range: 69 CAD through 933 CAD
Products Details
Product Description
– 4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.
Web ID
– T6363
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C11H8O4
Citations
– 1. Chen Y, Wu Z, Huang S, et al. Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis. Nature Metabolism. 2022: 1-19.
2. Cai J, Zhang X, Chen P, et al. The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury. Journal of Biological Chemistry. 2021: 101532.
3. Luo R, Wei Y, Chen P, et al.Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1α Branch of the Endoplasmic Reticulum Stress Response.Stem Cells International.2023, 2023.
4. Gao K, Yi Y, Xue Z, et al.Downregulation of XBP1s aggravates lipopolysaccharide-induced inflammation by promoting NF-κB and NLRP3 pathways’ activation in goat endometrial epithelial cells.Theriogenology.2023
5. Liu S, Zhang X, Yao X, et al.Mammalian IRE1α dynamically and functionally coalesces with stress granules.Nature Cell Biology.2024: 1-15.
6. Zheng M, Zhai Y, Yu Y, et al.TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response.Cell Metabolism.2024
References
– Cross BC, et al. Proc Natl Acad Sci U S A. 2012, 109(15), E869-878.
CAS Number
– 14003-96-4
Molecular Weight
– C11H8O4
Compound Purity
– 0.9861
SMILES
– Cc1cc(=O)oc2c(C=O)c(O)ccc12
Pathway
– Cell Cycle/Checkpoint
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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