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Product Description
– 3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces p53-dependent apoptosis, induces p53 accumulation and activates MAPK phosphorylation[1][2].
Web ID
– HY-126849
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C6H10N4O2
References
– [1]He Y, et al. 3-morpholinosydnonimine (SIN-1)-induced oxidative stress leads to necrosis in hypertrophic chondrocytes in vitro. Biomed Pharmacother. 2018 Oct;106:1696-1704. |[2]Kaji T, et al. 3-Morpholinosydnonimine hydrochloride induces p53-dependent apoptosis in murine primary neural cells: a critical role for p21(ras)-MAPK-p19(ARF) pathway. Nitric Oxide. 2002 Mar;6(2):125-34.
CAS Number
– 33876-97-0
Molecular Weight
– 170.17
SMILES
– [NH-]C1=C[N+](N2CCOCC2)=NO1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MDM-2/p53
Pathway
– Apoptosis
Product type
– Biochemical Assay Reagents
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