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Product Description
– 2′,3′-cGAMP-C2-PPA is a cyclic dinucleotide stimulator of interferon genes (STING) agonist. 2′,3′-cGAMP-C2-PPA binds to stimulator of interferon genes (STING) resulting in oligomerization, then stimulates the expression of type I interferons (IFNs) and pro-inflammatory cytokines to induce an immune response. 2′,3′-cGAMP-C2-PPA can be used for immune and tumor disease research[1].
Web ID
– HY-141662
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H36N10O14P2S2
References
– [1]Stazzoni S, et al. Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists. Angew Chem Int Ed Engl. 2022 Oct 4;61(40):e202207175.|[2]Chen Z, et, al. Antibody-sting agonist conjugates and their use in immunotherapy. US20210015941A1.
CAS Number
– 2586047-11-0
Molecular Weight
– 850.71
SMILES
– OC(CCC(C)SSCC[C@H]1[C@]2([H])[C@@](N3C4=C(C(N=C(N4)N)=O)N=C3)([H])O[C@]1([H])COP(O)(O[C@]5([H])[C@@](O[C@](N6C7=NC=NC(N)=C7N=C6)([H])[C@@H]5O)([H])COP(O)(O2)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Drug-Linker Conjugates for ADC;STING
Pathway
– Antibody-drug Conjugate/ADC Related;Immunology/Inflammation
Product type
– ADC Related
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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