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2-Thiouracil
$50 – $55
Products Details
Product Description
– 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM[1][2].
Web ID
– HY-B0503
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C4H4N2OS
References
– [1]Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12.|[2]Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201.
CAS Number
– 141-90-2
Molecular Weight
– 128.15
Compound Purity
– 99.87
SMILES
– O=C(C=CN1)NC1=S
Clinical Information
– No Development Reported
Research Area
– Endocrinology; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Target
– NO Synthase
Isoform
– nNOS
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
