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15-Deoxy-Δ-12,14-prostaglandin J2
$390
Only 1000 item(s) left in stock.
Products Details
Product Description
– 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].
Web ID
– HY-108568
Storage Temperature
– Solution, -20°C, 2 years
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C20H28O3
References
– [1]Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278.|[2]Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.
CAS Number
– 87893-55-8
Molecular Weight
– 316.43
Compound Purity
– 99.0
SMILES
– CCCCC/C=C/C=C1[C@H](C=CC1=O)C/C=CCCCC(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;PPAR
Isoform
– Human Endogenous Metabolite;PPARβ/δ;PPARγ
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
