1-Caffeoylquinic acid

SKU HY-N0460-1 mg Category Tags ,

$85$340

Products Details

Product Description

– 1-Caffeoylquinic acid is an effective NF-κB inhibitor, shows significant binding affinity to the RH domain of p105 with Ki of 0.002 μM and binding energy of 1.50 Kcal/mol[1]. 1-Caffeoylquinic acid has anti-oxidative stress ability[2]. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact[3].

Web ID

– HY-N0460

Storage Temperature

– 4°C (Powder, protect from light)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C16H18O9

References

– [1]Khan MK, et al. Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacogn Mag. 2013 Jan;9(33):51-7.|[2]Jiang Y, et al. Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model. BMC Complement Altern Med. 2017 Jun 17;17(1):320.|[3]Han Y, et al. PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy. Anal Biochem. 2018 Apr 15;547:52-56.

CAS Number

– 1241-87-8

Molecular Weight

– 354.31

Compound Purity

– 99.0

SMILES

– O[C@@H]1[C@H](O)C[C@@](OC(/C=C/C2=CC(O)=C(O)C=C2)=O)(C(O)=O)C[C@H]1O

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 250 mg/mL (ultrasonic)

Target

– NF-κB

Pathway

– NF-κB

Product type

– Natural Products

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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