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γ-Oryzanol
$50 – $60
Products Details
Product Description
– γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).
Web ID
– HY-B2194
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C40H58O4
References
– [1]Kozuka C, et al. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia. 2017 Aug;60(8):1502-1511.
CAS Number
– 11042-64-1
Molecular Weight
– 602.89
Compound Purity
– 95.0
SMILES
– C[C@@H]([C@@]1([H])CC[C@]2(C)[C@]1(C)CCC34C2CCC5[C@@]3(CC[C@H](OC(/C=C/C6=CC(OC)=C(O)C=C6)=O)C5(C)C)C4)CC/C=C(C)C
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cancer
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)
Target
– DNA Methyltransferase
Isoform
– DNMT1;DNMT3
Pathway
– Epigenetics
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
