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γ-L-Glutamyl-L-alanine
SKU
HY-112171-100 mg
Category Reference compound
Tags CaSR;Endogenous Metabolite, GPCR/G Protein;Metabolic Enzyme/Protease, Others
$90 – $190
Products Details
Product Description
– γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function[1][2][3][4].
Web ID
– HY-112171
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C8H14N2O5
References
– [1]Ovchinnikova OG, et al. Structure of a polysaccharide from Providencia rustigianii O11 containing a novel amide of 2-acetamido-2-deoxygalacturonic acid with L-glutamyl-L-alanine. Carbohydr Res. 2012 Feb 15;349:95-102.|[2]Broadhead GK, et al. Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids. J Biol Chem. 2011 Mar 18;286(11):8786-97. |[3]Tatsuo Yamamoto, et al. Further Characterization of Glutaminase Isozymes from Pseudomonas aeruginosa. |[4]York MJ, et al. gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect. Eur J Biochem. 1989 Sep 1;184(1):97-101.
CAS Number
– 5875-41-2
Molecular Weight
– 218.21
Compound Purity
– 98.0
SMILES
– OC([C@@H](N)CCC(N[C@@H](C)C(O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 1 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL
Target
– CaSR;Endogenous Metabolite
Isoform
– Human Endogenous Metabolite
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
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