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Products Details
Product Description
– β5i-IN-1 is a potent and selective inhibitor of β5i with a IC50 of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of NF-κB. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis[1].
Web ID
– HY-156297
Shipping
– Room temperature
Molecular Formula
– C22H20BN3O4S2
References
– [1]Li Y, et al. Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification. Eur J Med Chem. 2023 Dec 5;261:115856.
Molecular Weight
– 465.35
SMILES
– O=C1N(CCSC)/C(S/C1=CC2=CC=C(C3=CC=C(B(O)O)C=C3)O2)=N/C4=CC=CN=C4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Proteasome
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
