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Products Details
Product Description
– β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (Ki = 0.13 nM).
Web ID
– HY-139720
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C20H20F2N4O3S
References
– [1]Ueno T, et al. Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions. J Med Chem. 2021 Oct 14;64(19):14165-14174.
CAS Number
– 2760674-85-7
Molecular Weight
– 434.46
SMILES
– O=C(C1=CC2=C(OCCO2)C=N1)NC3=CC=C(F)C([C@@]4(C)N=C(N)S[C@H](C)[C@@H]4F)=C3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Beta-secretase
Isoform
– BACE1
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
