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Products Details
Product Description
– β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM – 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects[1].
Web ID
– HY-155313
Shipping
– Room temperature
Molecular Formula
– C59H92N8O19
References
– [1]Wang Y, et al. Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment. Bioorg Med Chem Lett. 2023 Oct 15;95:129493.
Molecular Weight
– 1217.40
SMILES
– CN(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](OC(N(CCN(C)C(OCC2=CC([N+]([O-])=O)=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O3)C=C2)=O)C)=O)C4=CC=CC=C4)=O)CCC1)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Others
Pathway
– Others
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
