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Products Details
Product Description
– β-Glucuronide-dPBD-PEG5-NH2 is a β-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate (ADC) cIRCR201-dPBD, utilizing a cleavable β-glucuronide linkage. This compound targets and binds to the prenylated antibody, facilitating controlled drug release to mitigate side effects and exhibits antitumor properties by inducing apoptosis and arresting the cell cycle [1].
Web ID
– T74437
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C78H101N7O35
CAS Number
– 2246363-68-6
Molecular Weight
– C78H101N7O35
SMILES
– [H][C@@]12CC(=C)CN1C(=O)c1cc(OC)c(OCCCCCOc3cc4N(C(O)[C@]5([H])CC(=C)CN5C(=O)c4cc3OC)C(=O)OCc3ccc(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)c(c3)C(=O)NCCOCCOCCOCCOCCOCCON)cc1N(C2O)C(=O)OCc1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)c(c1)C(=O)NCCOC
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– Small Compound
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