Download Files:
Products Details
Product Description
– β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. β-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. β-Glucuronide-dPBD-PEG5-NH2 has antitumor activity[1].
Web ID
– HY-145736
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C78H101N7O35
References
– [1]Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.
CAS Number
– 2246363-68-6
Molecular Weight
– 1696.66
SMILES
– NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[C@](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[C@](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)C(O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Drug-Linker Conjugates for ADC
Pathway
– Antibody-drug Conjugate/ADC Related;Apoptosis
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
