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Product Description
– α-Helical CRF (9-41) is a synthetic peptide antagonist that targets corticotropin-releasing factor (CRF), effectively inhibiting CRF-induced adrenocorticotropic hormone (ACTH) release both in vitro, with isolated rat anterior pituitary cells at concentrations of 0.5 to 5 µM, and in vivo, in non-anesthetized, intact rats at doses ranging from 0.02 to 0.6 µmol/kg. Moreover, it prevents stress-induced ACTH release at a dose of 0.6 µmol/kg in rats and demonstrates the ability to enhance social interaction times in a rat model addressing nicotine-induced conditioned anxiety, in addition to decreasing binge-like ethanol consumption in mice.
Web ID
– T83665
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C166H274N46O53S2.XCF3COOH
Molecular Weight
– C166H274N46O53S2.XCF3COOH
SMILES
– OC(CC[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC=N1)NC([C@@H](NC([C@]([H])([C@@H](C)O)NC([C@@H](NC([C@H](CC(O)=O)N[H])=O)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)C)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)=O.OC(C(F)(F)F)=O
Product type
– Peptide
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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