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Product Description
– α-Conotoxin Vc1.1 TFA is a disulfide-bonded peptide isolated from Conus victoriae and is a selective nAChR antagonist. α-Conotoxin Vc1.1 TFA inhibits α3α5β2, α3β2 and α3β4 with IC50s of 7.2 μM, 7.3 μM and 4.2 μM, respectively, and has less inhibitory effect on other nAChR subtypes. α-Conotoxin Vc1.1 TFA has the potential for neuropathic pain reserach[1][2].
Web ID
– HY-125777A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C73H104F3N23O27S4
References
– [1]Richard J Clark, et al. The Synthesis, Structural Characterization, and Receptor Specificity of the Alpha-Conotoxin Vc1.1. J Biol Chem. 2006 Aug 11;281(32):23254-63.|[2]Narmatha Satkunanathan, et al. Alpha-conotoxin Vc1.1 Alleviates Neuropathic Pain and Accelerates Functional Recovery of Injured Neurones. Brain Res. 2005 Oct 19;1059(2):149-58.
Molecular Weight
– 1921.00
SMILES
– O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CSSC[C@@H]1NC(CN)=O)([H])NC([C@@H](NC([C@@](CCC2)([H])N2C3=O)=O)CCCNC(N)=N)=O)=O)CC(N)=O)=O)CC(C=C4)=CC=C4O)=O)CC(O)=O)=O)CC5=CN=CN5)N(CCC6)[C@]6([H])C(N[C@H](C(N[C@@](C(N[C@@H](CSSC[C@](C(N[C@H](C(N[C@H]3CC(O)=O)=O)CO)=O)([H])NC1=O)C(N)=O)=O)([H])[C@@H](C)CC)=O)CCC(O)=O)=O.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– nAChR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
