Kinase Inhibitors

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Select a target to explore available kinase inhibitors. Counts reflect unique products in our collection.

Protein kinases are a superfamily of enzymes that catalyze the transfer of phosphate groups from ATP to specific substrates, regulating virtually every aspect of cell biology. The human kinome comprises over 500 protein kinases, making it one of the largest gene families. Small-molecule kinase modulators have become essential research tools for dissecting signaling networks and understanding how phosphorylation events control cell fate decisions in vitro.

Receptor tyrosine kinases (RTKs) such as EGFR, VEGFR, FGFR, and PDGFR sit at the cell surface and transduce extracellular signals into intracellular cascades. Upon ligand binding, RTKs undergo dimerization and autophosphorylation, activating downstream pathways including RAS/MAPK, PI3K/AKT, and JAK/STAT. Compounds targeting these receptors allow researchers to selectively interrupt specific signaling nodes and map pathway dependencies.

Non-receptor tyrosine kinases — including Src family kinases, BTK, and Bcr-Abl — relay signals from receptors to downstream effectors and play key roles in immune cell activation, cytoskeletal dynamics, and proliferative signaling. Our collection provides researchers with a comprehensive toolkit spanning both receptor and non-receptor kinases, enabling detailed mechanistic studies of phosphorylation-dependent signaling.