DNA Damage & Repair Compounds

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Select a target to explore available DNA damage and repair compounds. Counts reflect unique products in our collection.

The DNA damage response (DDR) is a complex signaling network that detects DNA lesions, activates cell cycle checkpoints, and coordinates repair processes. Cells encounter thousands of DNA lesions daily from endogenous sources such as reactive oxygen species and replication errors, as well as exogenous agents. Small-molecule modulators of DDR proteins are essential tools for dissecting these pathways in vitro.

Key repair pathways include base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR), and non-homologous end joining (NHEJ). Compounds targeting PARP enzymes, which play central roles in single-strand break repair and BER, are among the most widely studied tools in DDR research. ATR and ATM kinases serve as master regulators of the damage response, activating downstream effectors like Chk1 and Chk2.

Topoisomerases resolve the topological stress associated with DNA replication and transcription, and their modulators have been instrumental in studying replication fork dynamics and DNA supercoiling. Our collection provides researchers with a comprehensive set of tools for investigating every aspect of DNA damage sensing, signaling, and repair.