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AS1269574
$83 – $660
Products Details
Product Description
– AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].
Web ID
– HY-107535
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C13H14BrN3O
References
– [1]Yoshida S, et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010;400(3):437-441.|[2]Chepurny OG, et al. GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion. Mol Endocrinol. 2016;30(6):614-629.
CAS Number
– 330981-72-1
Molecular Weight
– 308.17
Compound Purity
– 98.76
SMILES
– OCCNC1=NC(C2=CC=C(Br)C=C2)=NC(C)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– GPR119;TRP Channel
Isoform
– TRPA
Pathway
– GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
