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Quizartinib
Price range: 85 CAD through 853 CAD
Products Details
Product Description
– Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
Web ID
– T2066
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H32N6O4S
Citations
– 1. Zhang Y, Wang P, Wang Y, et al.Sitravatinib as a potent FLT3 inhibitor can overcome gilteritinib resistance in acute myeloid leukemia.Biomarker Research.2023, 11(1): 1-16.
2. Huang F, Liang J, Lin Y, et al.Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis.Communications Biology.2023, 6(1): 972.
3. Wang P, Zhang Y, Xiang R, et al.Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib.Cancer Research.2024
4. Xu X, Xie T, Zhou M, et al.Hsc70 promotes anti-tumor immunity by targeting PD-L1 for lysosomal degradation.Nature Communications.2024, 15(1): 4237.
5. Hu C, Zhang Y, Yang J, et al.Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia.Cell Communication and Signaling.2024, 22(1): 1-14.
References
– Zarrinkar PP, et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009 Oct 1;114(14):2984-92.
CAS Number
– 950769-58-1
Molecular Weight
– C29H32N6O4S
Compound Purity
– 0.9848
SMILES
– CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Target
– Others
Pathway
– Apoptosis|||Angiogenesis|||Autophagy|||PROTAC|||Tyrosine Kinase/Adaptors
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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