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Products Details
Product Description
– HGC652 is a molecular glue that targets the E3 ubiquitin ligase TRIM21, facilitating the formation of a ternary complex between TRIM21 and NUP98, which induces the degradation of NUP155 and nuclear pore complex proteins, ultimately leading to cell death. HGC652 inhibits the proliferation of various cancer cells, with its antiproliferative activity depending on the expression level of TRIM21.
Web ID
– T204670
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C23H28FNO3S2
CAS Number
– 3055558-98-7
Molecular Weight
– C23H28FNO3S2
SMILES
– O=C(C=1C=CC(=CC1S(=O)(=O)C)C2=CC=C(F)C=C2SC)N(C)CC3CCCCC3
Target
– Drug-Linker Conjugates for ADC
Pathway
– PROTAC|||Ubiquitination
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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