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Products Details
Product Description
– KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.
Web ID
– TP1895
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C74H108N14O17
References
– Lamberto et al (2012) Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445 47 PMID:
CAS Number
– 676657-00-4
Molecular Weight
– C74H108N14O17
SMILES
– C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CO)=O)CO)=O)CC(C)C)=O)[C@H](C)C)=O)CCC1)NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CCCCN)N)=O)=O)CC(C)C)=O)CCC2)CC4=CC=C(O)C=C4)=O)C=5C=6C(NC5)=CC=CC6
Product type
– Peptide
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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