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Proguanil-d6 HCl
Price range: 1,045 CAD through 3,168 CAD
Products Details
Product Description
– Proguanil-d6 HCl is a deuterated compound of Proguanil HCl. Proguanil HCl has a CAS number of 637-32-1. Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
Web ID
– TMIH-0457
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C11H11D6Cl2N5
References
– 1. Gerlinde F. Plöger, etal. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride[J]. Journal of Pharmaceutical Sciences, 2018, 163(4):1-21.
Molecular Weight
– C11H11D6Cl2N5
SMILES
– N=C(NC(NC(C([2H])([2H])[2H])C([2H])([2H])[2H])=N)NC1=CC=C(Cl)C=C1.Cl
Product type
– Isotope products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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