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HQ461
Price range: 38 USD through 1,730 USD
Products Details
Product Description
– HQ461 is a molecular glue that promotes CDK12-DDB1 interaction, triggering cyclin K degradation, decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
Web ID
– T9849
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C15H15N5OS2
References
– Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.
CAS Number
– 1226443-41-9
Molecular Weight
– C15H15N5OS2
Compound Purity
– 0.9811
SMILES
– Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
Pathway
– Cell Cycle/Checkpoint|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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