Download Files:
Products Details
Product Description
– COMT-IN-1 (compound C12) is a nitrophenol analog and an orally active catechol-O-methyltransferase (COMT) inhibitor. It exhibits IC50 values of 0.37 μM for COMT, 95.58 μM for MAO-A, and 58.82 μM for MAO-B, demonstrating its inhibitory activity on these enzymes. Additionally, COMT-IN-1 displays chelation properties with various metal ions and has good blood-brain barrier permeability. This compound enhances dopamine levels in mice and ameliorates symptoms of MPTP-induced Parkinsons disease (PD).
Web ID
– T89119
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H18FN3O6
CAS Number
– 2987884-27-3
Molecular Weight
– C24H18FN3O6
SMILES
– FC1=CC=CC(COC(C=C2)=CC=C2CNC(/C(C#N)=C/C3=CC([N+]([O-])=O)=C(C(O)=C3)O)=O)=C1
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
