– Stromatoxin 1, a peptide isolated from tarantulas, acts as an inhibitor of various potassium channels, including K(V)2.1, K(V)2.2, K(V)4.2, and K(V)2.1/9.3. It selectively targets K(V)2.1 and K(V)2.2 channel subunits, which are crucial in counteracting myogenic and neurogenic contractions of rat urinary bladder smooth muscle (UBSM) [1].