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Product Description
– Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model. Formulations containing flutamide have been used in the treatment of prostate cancer.
Web ID
– T69758
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C11H4D7F3N2O3
CAS Number
– 223134-72-3
Molecular Weight
– C11H4D7F3N2O3
SMILES
– C(F)(F)(F)C1=C(N(=O)=O)C=CC(NC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=O)=C1
Product type
– Isotope products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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