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PX-478
Price range: 77 CAD through 731 CAD
Products Details
Product Description
– PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 diabetes mellitus research.
Web ID
– T6961
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C13H20Cl4N2O3
Citations
– 1. Chang L L, Lu P H, Yang W, et al. AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1α and metabolic reprogramming. Translational Oncology. 2022, 20: 101421
2. Liu R, Tian Y, Wang J, et al.Visible light–initiated radical 1,3-difunctionalization of β, γ-unsaturated ketones.Science Advances.2022, 8(49): eabq8596.
References
– Koh MY, et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Mol Cancer Ther. 2008 Jan;7(1):90-100.
CAS Number
– 685898-44-6
Molecular Weight
– C13H20Cl4N2O3
SMILES
– Cl.Cl.N[C@@H](Cc1ccc(cc1)[N+]([O-])(CCCl)CCCl)C(O)=O
Pathway
– Angiogenesis|||Chromatin/Epigenetic|||Metabolism|||Autophagy
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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