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Bafetinib
Price range: 50 CAD through 766 CAD
Products Details
Product Description
– Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.
Web ID
– T6311
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C30H31F3N8O
Citations
– 1. Jing Y, Dai X, Yang L, et al. STING couples with PI3K to regulate actin reorganization during BCR activation. Science Advances. 2020, 6(17): eaax9455.
2. Wu J, Nie Y, Wang J, et al. Fcγ receptor‐mediated phagocytosis pathway was involved in phagocytosis of mIgM+ B lymphocytes from largemouth bass (Micropterus salmoides). Journal of Fish Biology. 2022
3. Weng H, Xiong K P, Wang W, et al.Aspartoacylase suppresses prostate cancer progression by blocking LYN activation.Military Medical Research.2023, 10(1): 1-25.
References
– Kimura S, et al. Blood. 2005, 106(12), 3948-3954.
CAS Number
– 859212-16-1
Molecular Weight
– C30H31F3N8O
Compound Purity
– 0.9968
SMILES
– CN(C)[C@H]1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncnc3)c2)C1
Pathway
– Tyrosine Kinase/Adaptors|||Autophagy|||Cytoskeletal Signaling|||Angiogenesis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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