Download Files:
Bemcentinib
Price range: 54 CAD through 1,595 CAD
Products Details
Product Description
– Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
Web ID
– T6269
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C30H34N8
Citations
– 1. Huang M, Liu M, Huang D, et al. Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway. Cancer Letters. 2021
2. Yuan Y, Guo Y, Guo Z W, et al.Marsdenia tenacissima extract induces endoplasmic reticulum stress-associated immunogenic cell death in non-small cell lung cancer cells through targeting AXL.Journal of Ethnopharmacology.2023: 116620.
References
– Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70(4):1544-54.
CAS Number
– 1037624-75-1
Molecular Weight
– C30H34N8
Compound Purity
– 0.9958
SMILES
– Nc1nc(Nc2ccc3CC[C@@H](CCc3c2)N2CCCC2)nn1-c1cc2CCCc3ccccc3-c2nn1
Pathway
– Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
