Dorsomorphin dihydrochloride

SKU T6146-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 1,579 CAD

Products Details

Product Description

– Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.

Web ID

– T6146

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C24H25N5O·2HCl

Citations

– 1. Xu J, Ao Y L, Huang C, et al. Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway. npj Parkinson’s Disease. 2022, 8(1): 1-12. 2. Fan C, Feng J, Tang C, et al. Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage. Stem Cell Research & Therapy. 2020, 11(1): 1-22 3. Qiu W Q, Pan R, Tang Y, et al. Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction. Biomedicine & Pharmacotherapy. 2020, 130: 110575. 4. Cao P, Wang Y, Zhang C, et al.Quercetin ameliorates non-alcoholic fatty liver disease (NAFLD) via the promotion of AMPK-mediated hepatic mitophagy.The Journal of Nutritional Biochemistry.2023: 109414. 5. Qin W, Ding Y, Zhang W, et al.Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD.Journal of Lipid Research.2025: 100740.

References

– Li N, et al. Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels. Cancer Biol Med. 2019 May;16(2):220-233.

CAS Number

– 1219168-18-9

Molecular Weight

– C24H25N5O·2HCl

Compound Purity

– 0.9889

SMILES

– Cl.Cl.C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1

Pathway

– Stem Cells|||Chromatin/Epigenetic|||Autophagy|||PI3K/Akt/mTOR signaling

Product type

– Small Compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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