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ARV-771
Price range: 88 CAD through 1,341 CAD
Products Details
Product Description
– ARV-771 is an effective BET degrader based on PROTAC technology. The Kd for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2) are 34 and 4.7 respectively. , 8.3, 7.6, 9.6 and 7.6 nM.
Web ID
– T5435
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C49H60ClN9O7S2
Citations
– 1. Stickler S, Lang C, Rieche M, et al.Characterization of a pleomorphic rhabdomyosarcoma cell line.Scientific Reports.2025, 15(1): 2893.
References
– Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 201. Jun 28;113(26):7124-9.
CAS Number
– 1949837-12-0
Molecular Weight
– C49H60ClN9O7S2
Compound Purity
– 0.9969
SMILES
– CC=1C2=C(N3C([C@H](CC(NCCOCCCOCC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C
Pathway
– PROTAC|||Chromatin/Epigenetic
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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