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TGN-020
Price range: 75 CAD through 571 CAD
Products Details
Product Description
– TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.
Web ID
– T5102
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C8H6N4OS
Citations
– 1. Guo S, Song Z, He J, et al. Akt/aquaporin-4 signaling aggravates neuropathic pain by activating astrocytes after spinal nerve ligation in rats. Neuroscience. 2021
2. Murdock M H, Yang C Y, Sun N, et al.Multisensory gamma stimulation promotes glymphatic clearance of amyloid.Nature.2024: 1-8.
3. Wu W, Zhao Y, Cheng X, et al.Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease.Nature Communications.2025, 16(1): 63.
References
– Huber VJ, et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009 Jan 1;17(1):411-7.
CAS Number
– 51987-99-6
Molecular Weight
– C8H6N4OS
Compound Purity
– 0.9989
SMILES
– O=C(Nc1nncs1)c1cccnc1
Pathway
– Membrane transporter/Ion channel|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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