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5-(N,N-Hexamethylene)-amiloride
Price range: 80 CAD through 240 CAD
Products Details
Product Description
– 5-(N,N-Hexamethylene)-amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM). It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.
Web ID
– T4699
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C12H18ClN7O
References
– Banke T G . The dilated TRPA1 channel pore state is blocked by amiloride and analogues.[J]. Brain Research, 2011, 1381(1381):21-30.
CAS Number
– 1428-95-1
Molecular Weight
– C12H18ClN7O
SMILES
– NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1
Pathway
– Microbiology/Virology|||Neuroscience|||Membrane transporter/Ion channel|||Apoptosis|||Proteases/Proteasome
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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