dBET1

SKU T4495-1 mL * 10 mM (in DMSO) Category PROTAC Brand: TargetMol

Price range: 77 CAD through 2,384 CAD

Size

1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Product Description

– dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.

Web ID

– T4495

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C38H37ClN8O7S

References

– Winter GE, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348(6241):1376-81.

CAS Number

– 1799711-21-9

Molecular Weight

– C38H37ClN8O7S

Compound Purity

– 0.993

SMILES

– CC=1C2=C(N3C([C@H](CC(NCCCCNC(COC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C

Pathway

– Chromatin/Epigenetic|||PROTAC

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

dBET1

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