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Products Details
Product Description
– GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cellsin vitroand in cardiomyocytes.
Web ID
– T41232
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C18H21ClFN3OS
References
– Washburn et al (2013) The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg.Med.Chem.Lett. 23 4979 PMID: 23886683
CAS Number
– 1366234-01-6
Molecular Weight
– C18H21ClFN3OS
SMILES
– C(=O)(C=1N=C(NC2=C(F)C=C(Cl)C=C2)SC1C)N3[C@@H](C)[C@@H](C)CCC3
Pathway
– Others
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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