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MS21
2,432 CAD
Only 1000 item(s) left in stock.
Products Details
Product Description
– MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.
Web ID
– T39929
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C58H79ClN12O6S
References
– Xu J, et al. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer Discov. 2021 Jul 23.
CAS Number
– 2376137-05-0
Molecular Weight
– C58H79ClN12O6S
SMILES
– Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N2CCN(CC[C@H](NC(=O)C3(N)CCN(CC3)c3ncnc4[nH]ccc34)c3ccc(Cl)cc3)CC2)C(C)(C)C)cc1
Pathway
– PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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