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Product Description
– Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells.
Web ID
– T38484
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C26H34O6
Citations
– 1. Yang L, Peng Z, Gong F, et al.TRPC4 Aggravates Hypoxic Pulmonary Hypertension by Promoting Pulmonary Endothelial Cell Apoptosis.Free Radical Biology and Medicine.2024
References
– Akbulut Y, et al. (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91.
CAS Number
– 1094250-15-3
Molecular Weight
– C26H34O6
SMILES
– [H][C@@]12CC[C@@H](C)[C@@]1([H])[C@H](OC(=O)C=Cc1ccccc1)[C@@]1(C[C@@H](OC(=O)CO)[C@@]2(C)O1)C(C)C
Pathway
– Membrane transporter/Ion channel
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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