Download Files:
BMS-1
Price range: 77 CAD through 2,448 CAD
Products Details
Product Description
– BMS-1 (PD-1/PD-L1 inhibitor 1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.
Web ID
– T3655
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H33NO5
Citations
– 1. Zhao Y, Hao C, Li M, et al. PD-1/PD-L1 inhibitor ameliorates silica-induced pulmonary fibrosis by maintaining systemic immune homeostasis. Biomedicine & Pharmacotherapy. 2022, 148: 112768.
2. Choi J G, Kim Y S, Kim J H, et al. Anticancer effect of Salvia plebeia and its active compound by improving T-cell activity via blockade of PD-1/PD-L1 interaction in humanized PD-1 mouse model. Frontiers in immunology. 2020 Nov 5;11:598556. doi: 10.3389
References
– Chupak Louis S,et al. From PCT Int. Appl. (2015), WO 2015034820 A1 20150312.
CAS Number
– 1675201-83-8
Molecular Weight
– C29H33NO5
Compound Purity
– 0.9986
SMILES
– COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CN1CCCC[C@H]1C(O)=O
Pathway
– Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
