CMC2.24
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CMC2.24

SKU T36492-25 mg Category Brand:

Price range: 1,576 CAD through 3,104 CAD

Products Details

Product Description

– CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3].

Web ID

– T36492

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H21NO5

References

– Mallangada NA, et al. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras. Mol Carcinog. 2018;57(9):1130-1143.

CAS Number

– 1255639-43-0

Molecular Weight

– C26H21NO5

SMILES

– Oc1ccc(C=CC(=O)C(C(=O)Nc2ccccc2)C(=O)C=Cc2ccc(O)cc2)cc1

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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