Download Files:
SHP099 hydrochloride
Price range: 51 CAD through 2,224 CAD
Products Details
Product Description
– SHP099 hydrochloride is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 70 nM, which inhibits ERK1/2 activation in cancer cells. [2]
Web ID
– T3544
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H20Cl3N5
Citations
– 1. Qiu W Q, Ai W, Zhu F D, et al. Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Free Radical Biology and Medicine. 2022, 179: 76-94.
2. Zheng M, Liu Y, Wu C, et al. Novel PROTACs for degradation of SHP2 protein. Bioorganic Chemistry. 2021, 110: 104788
References
– Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82.
CAS Number
– 2200214-93-1
Molecular Weight
– C16H20Cl3N5
Compound Purity
– 0.9962
SMILES
– Cl.CC1(N)CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl
Target
– Others
Pathway
– Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
