Wedelolactone
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Wedelolactone

SKU T3384-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 48 CAD through 1,696 CAD

Products Details

Product Description

– Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

Web ID

– T3384

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H10O7

Citations

– 1. Pan H, Lin Y, Dou J, et al. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis. Cell Proliferation. 2020, 53(9): e12868 2. ROMANCHIKOVA N, TRAPENCIERIS P. Wedelolactone Targets EZH2-mediated Histone H3K27 Methylation in Mantle Cell Lymphoma. Anticancer Research. 2019, 39(8): 4179-4184 3. Wang Z, Yan H, He F, et al.Inhibition of Herpes Simplex Virus by Wedelolactone via Targeting Viral Envelope and Cellular TBK1/IRF3 and SOCS1/STAT3 pathways.International Journal of Antimicrobial Agents.2023: 107000. 4. Chen J, Zhou X, Fu L, et al.Natural Product-Based Screening for Lead Compounds Targeting SARS CoV-2 Mpro[J]. Pharmaceuticals, 2023, 16(5): 767..Pharmaceuticals.2023, 16(5): 767. 5. Chen P, Zhu Z, Geng H, et al.Integrated Spatial Metabolomics and Transcriptomics Decipher the Hepatoprotection Mechanisms of Wedelolactone and Demethylwedelolactone on Non-alcoholic Fatty Liver Disease.Journal of Pharmaceutical Analysis.2023 6. Cai R, Gong X, Li X, et al.Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.Respiratory Research.2024, 25(1): 1-19.

References

– Nehybová T, et al. Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells. Int J Mol Sci. 2017 Mar 29;18(4).

CAS Number

– 524-12-9

Molecular Weight

– C16H10O7

Compound Purity

– 0.9987

SMILES

– COc1cc(O)c2c3oc4cc(O)c(O)cc4c3c(=O)oc2c1

Pathway

– Apoptosis|||NF-κB|||Metabolism|||Proteases/Proteasome

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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