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SGC0946
Price range: 62 CAD through 1,434 CAD
Products Details
Product Description
– SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.
Web ID
– T3082
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H40BrN7O4
Citations
– 1. Yu S, Zhou C, He J, et al. BMP4 drives primed to naïve transition through PGC-like state. Nature Communications. 2022, 13(1): 1-15
2. Wang W, Ren S, Lu Y, et al. Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production. The EMBO Journal. 2021 Jun 1;40(11):e106771. doi: 10.15252/embj.2020106771. Epub 2021 Apr 28.
3. Chen R, Xie W, Cai B, et al. Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs). Stem Cells International. 2018 Dec 25;2018:5965727
4. Liu C, Li J, Xu F, et al.PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer.Molecular Cancer.2024, 23(1): 111.
References
– Yu W, et al. Nat Commun, 2012, 3, 1288.
CAS Number
– 1561178-17-3
Molecular Weight
– C28H40BrN7O4
Compound Purity
– 0.9982
SMILES
– CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Br)c2c(N)ncnc12
Pathway
– Chromatin/Epigenetic
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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