GS-462808
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GS-462808

SKU T27437-25 mg Category Brand:

Price range: 2,432 CAD through 4,000 CAD

Products Details

Product Description

– GS-462808 is a late sodium current inhibitor of the cardiac Nav1.5 channel. GS-462808 had lower brain penetration and serendipitously lower activity at the brain isoforms.

Web ID

– T27437

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H12F3N5O3

References

– Koltun DO, Parkhill EQ, Elzein E, Kobayashi T, Jiang RH, Li X, Perry TD, Avila B, Wang WQ, Hirakawa R, Smith-Maxwell C, Wu L, Dhalla AK, Rajamani S, Mollova N, Stafford B, Tang J, Belardinelli L, Zablocki JA. Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3207-11. doi: 10.1016/j.bmcl.2016.03.096. Epub 2016 Mar 26. PubMed PMID: 27038498.

CAS Number

– 1354198-41-6

Molecular Weight

– C17H12F3N5O3

SMILES

– O=C1N2C(=NN1CC3=NC(C)=NO3)C=CC(=C2)C4=CC=C(OC(F)(F)F)C=C4

Pathway

– Others

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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