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Bavdegalutamide
Price range: 130 CAD through 1,648 CAD
Products Details
Product Description
– Bavdegalutamide (ARV-110) is an oral protein degrader that specifically binds to AR and mediates its degradation. Bavdegalutamide can degrade clinically relevant mutant AR proteins, maintain activity in a high androgen environment, and has an acceptable safety profile.
Web ID
– T22263
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C41H43ClFN9O6
Citations
– 1. Sun R, Yan B, Li H, et al.Androgen receptor variants confer castration resistance in prostate cancer by counteracting antiandrogen-induced ferroptosis.Cancer Research.2023
2. Xiao M, Ha S, Zhu J, et al.Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer.Journal of Medicinal Chemistry.2024
References
– Taavi Neklesa, et al. ARV-110: An androgen receptor PROTAC degrader for prostate cancer. American Association for Cancer Research. 2018. 78 (13): pp. 5236.
CAS Number
– 2222112-77-6
Molecular Weight
– C41H43ClFN9O6
Compound Purity
– 0.9904
SMILES
– O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCN(CC5CCN(CC5)C6=CC=C(C(N[C@@H]7CC[C@@H](OC8=CC(Cl)=C(C#N)C=C8)CC7)=O)N=N6)CC4
Target
– Drug-Linker Conjugates for ADC
Pathway
– Endocrinology/Hormones
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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