JGB1741

SKU T22094-1 mg Category Small Compound Brand: TargetMol

Price range: 86 CAD through 1,696 CAD

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Product Description

– JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.

Web ID

– T22094

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C27H24N2O2S

References

– Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401(1):13-9.

CAS Number

– 1256375-38-8

Molecular Weight

– C27H24N2O2S

Compound Purity

– 0.9724

SMILES

– Oc1ccc2ccccc2c1C=Nc1sc2CCCCc2c1C(=O)NCc1ccccc1

Pathway

– Chromatin/Epigenetic|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

JGB1741

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