Download Files:
Y-27632
Price range: 59 CAD through 682 CAD
Products Details
Product Description
– Y-27632 is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
Web ID
– T1870
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H21N3O
Citations
– 1. Chen Y P, Shao Y, Chen P C, et al.Substrate nesting guides cyst morphogenesis of human pluripotent stem cells without 3D extracellular matrix overlay.Acta Biomaterialia.2023
2. Wang X, Liang X, Zhou L, et al. Yes-associated protein reacts differently in vascular smooth muscle cells under different intensities of mechanical stretch. Aging (Albany NY). 2022, 14(1): 286.
3. Xu L, Wang G, Shi R, et al.A cocktail of small molecules maintains the stemness and differentiation potential of conjunctival epithelial cells.The Ocular Surface.2023
4. He W, Zhu X, Xin A, et al. Long-term maintenance of human endometrial epithelial stem cells and their therapeutic effects on intrauterine adhesion. Cell & Bioscience. 2022, 12(1): 1-20.
5. Tao Z, Cui Y, Xu X, et al. FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma. Proceedings of the National Academy of Sciences. 2022, 119(40): e2208844119.
6. Schenke M, Prause H C, Bergforth W, et al. Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1. Toxins. 2021, 13(8): 585.
7. Housmans B A C, Neefjes M, Surtel D A M, et al. Synovial fluid from end-stage osteoarthritis induces proliferation and fibrosis of articular chondrocytes via MAPK and RhoGTPase signaling. Osteoarthritis and Cartilage. 2022
8. Lv J Q, Chen P C, Chen Y P, et al.Active hole formation in epithelioid tissues.Nature Physics.2024: 1-11.
9. Zhao Y, Pan Z, Hong Z, et al.Protocol for scarless genome editing of human pluripotent stem cell based on orthogonal selective reporters.STAR protocols.2024, 5(2): 103084.
10. Yang Y, Suo N, Cui S, et al.Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2024: 1-13.
References
– Wu Y, et al. ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3. Theriogenology. 2016 Jan 15;85(2):302-14.
CAS Number
– 146986-50-7
Molecular Weight
– C14H21N3O
Compound Purity
– 0.9987
SMILES
– C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Target
– LPA Receptor|||LPL Receptor
Pathway
– Stem Cells|||Cell Cycle/Checkpoint|||Apoptosis|||Cytoskeletal Signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
