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Ibrutinib
Price range: 54 CAD through 229 CAD
Products Details
Product Description
– Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
Web ID
– T1835
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C25H24N6O2
Citations
– 1. Guo W, Liang D, Wang P, et al. HIF-PH Encoded by EGLN1 Is a Potential Therapeutic Target for Chronic Lymphocytic Leukemia. Pharmaceuticals. 2022, 15(6): 734
2. Huang F, Liang J, Lin Y, et al.Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis.Communications Biology.2023, 6(1): 972.
3. Zhang Z, Zhou H, Gu W, et al.CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes.Nature Chemical Biology.2024: 1-11.
References
– Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.
CAS Number
– 936563-96-1
Molecular Weight
– C25H24N6O2
Compound Purity
– 0.9993
SMILES
– NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5)=NC=N1
Target
– Others
Pathway
– Angiogenesis|||PROTAC|||Tyrosine Kinase/Adaptors
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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